327ASSESSING THE EFFECTIVENESS OF EXCIMER LASER MONOTHERAPY VERSUS COMBINATION THERAPY IN MANAGING LOCALIZED PLAQUE PSORIASISPsoriasis, a chronic inflammatory skin disorder, is primarily characterized by the excessive proliferation of keratinocytes, leading to the formation of scaly, thickened plaques. Among the various types, localized plaque psoriasis is the most common, accounting for around 90% of all cases. This study aims to compare the efficacy of 308 nm excimer laser monotherapy versus its combination with topical treatments in managing localized plaque psoriasis. The excimer laser is a precise form of ultraviolet B (UVB) phototherapy that delivers focused light to affected areas, reducing T-cell proliferation and normalizing keratinocyte activity. This research involved 50 patients diagnosed with localized plaque psoriasis, who were divided into two groups: one receiving excimer laser monotherapy and the other receiving combination therapy (excimer laser plus topical corticosteroids). Treatment outcomes were assessed based on the reduction in Psoriasis Area and Severity Index (PASI) scores, lesion resolution times, and remission duration. Results indicated that combination therapy resulted in faster lesion resolution and greater clinical improvement compared to monotherapy. Specifically, 20 out of 25 patients in the combination group showed significant improvement within 2-3 weeks, whereas 15 out of 25 in the monotherapy group improved after 4 weeks. These findings suggest that combining excimer laser therapy with topical corticosteroids enhances treatment efficacy, offering more rapid and durable symptom relief for localized plaque psoriasis. Further studies are needed to explore the long-term benefits and potential risks of this combined approach.Ashwak@gmail.comResearch922019Localized Plaque Psoriasis, Excimer Laser, Combination Therapy, Corticosteroids, Uvb Phototherapy, Lesion Resolution, Treatment Efficacy.Dr. Ashwak Ahmed,Dr.Chandan AAssistant Professors, Department of Dermatology, PSP Medical College Hospital and Research Institute Chennai, Tamil Nadu, India,Assistant Professor, Department of Dermatology, Narayana Medical College and Hospital, Nellore, Andhra Pradesh, India