334A STUDY ON PREVALENCE OF INSULIN RESISTANCE IN NONDIABETIC OVERWEIGHT AND OBESE INDIVIDUALS IN KONASEEMA INSTITUTE OF MEDICAL SCIENCES AND RESEARCH FOUNDATIONObesity is a significant health concern associated with metabolic disorders, including insulin resistance. Aims and objectives This study aims to determine the prevalence of insulin resistance in non-diabetic overweight and obese individuals and analyze associated risk factors. Methods: Total of 150 obese and overweight patients who satisfied the above criteria were studied and analysed. Obesity is defined as BMI ?25 according to WHO definition of overweight in Asian population. Obese patients attending the out- patient department of general medicine at KIMS & RF amalapuram, Andhra Pradesh for minor ailments were included in the study. All the patients who are non-diabetic and presenting with overweight and obesity during the study period, who met the inclusion criteria and also who were willing to participate in this study. Result: In our present study the mean value of homo-IR for non-smokers was 3.85 and for smokers, it was 5.09. The mean Grade I of subjects was 3.57, Grade II was 4.44, Grade III was 6.07 and Grade IV was 7.73. ANOVA test was done here to compare the significant difference among mean value of Acanthosis score at different grades and the results were found to be significant. The mean Homa-IR was 3.17 for Acanthosis Nigricans and 4.91 for Non- Acanthosis Nigricans. T test was done here to compare the significant difference among mean value of HOMA-IR among Acanthosis Nigricans and NonAcanthosis Nigricans and the results were found to be significant. Conclusion: On the basis of our present study there is an increased prevalence of insulin resistance among non-diabetic obese individuals. In the insulin resistant group, males outnumbered the females. Age is an important risk factor for insulin resistance and the insulin resistance increases with age. Smoking, acanthosis nigricansis positively associated with insulin resistance.Badugu@gmail.comResearch1512025Hyperglycemia. Insulin Resistance, Obesity, OverweightDr. Pamula Sri Gowthami,Dr. Shaik Habeeba,Dr. Badugu Karun ManojHouse surgeon, Konaseema Institute of Medical Sciences and Research Foundation, Amalapuram, Andhra Pradesh, India,House surgeon, Konaseema Institute of Medical Sciences and Research Foundation, Amalapuram, Andhra Pradesh, India,Senior Resident, Department of General Medicine, Konaseema Institute of Medical Sciences and Research Foundation, Amalapuram, Andhra Pradesh, India