337EVALUATION OF THE ANTIDIABETIC ACTIVITY OF SELECTED PLANT USING STREPTOZOTOCIN AND NICOTINAMIDE INDUCED DIABETES IN ALBINO WISTAR RATSThe increasing prevalence of diabetes mellitus has led to a growing interest in exploring alternative therapeutic agents, particularly from plant-based sources. The study aimed to evaluate the antidiabetic potential of Persicaria hydropiper (P. hydropiper) in streptozotocin (STZ) and nicotinamide-induced diabetic Albino Wistar rats. Diabetes was induced in Albino Wistar rats through the intraperitoneal administration of streptozotocin (60 mg/kg) following a nicotinamide pre-treatment (100 mg/kg). The rats were divided into several groups: a diabetic control group, a standard treatment group (treated with Pioglitazone, 4 mg/kg), and experimental groups treated with varying doses of P. hydropiper extract (250 mg/kg and 500 mg/kg). Fasting blood glucose levels were measured at regular intervals, and body weight, organ weight, and histopathological evaluations were per formed at the end of the treatment period. The administration of P. hydropiper extract resulted in a significant reduction in blood glucose levels in a dose-dependent manner compared to the diabetic control group. The highest dose (500 mg/kg) showed the most substantial decrease in blood glucose, closely comparable to the standard Pioglitazone treatment and exhibited protective effects on pancreatic tissue as evidenced by histopathological findingsjothies82@gmail.comResearch1512025Persicaria hydropiper (P.hydropiper), Diabetes Mellitus (DM),Streptozotocin (STZ), NicotinamideDabbadi Pavan1, Ragini V2, Jothieswari D3*, Ravi Kiran D4, Jeevana K5, Satyam jha1M. Pharm, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India 2Professor and Head, Department of Pharmacology, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India 3Principal and Professor, Department of Pharmaceutical Analysis, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India.