339TREATMENT OF DIABETIC, CANCER BASED ON THE MEASUREMENT OF URINARY 8-HYDROXYDEOXYGUANANOSINE LEVELSBoth diabetes and cancer cause oxidative stress and the creation of free radicals which make it more difficult to treat and control patients. Here, we aimed to establish whether urinary 8-Hydroxydeoxyguanosine (8-OHdG) reflects cellular oxidative stress in diabetic cancer patients and can show the effects of chemotherapy. A group of 100 diabetic patients recently diagnosed with cancer and starting chemotherapy in an oncology unit were included in a controlled prospective observational study. Urinary 8-OHdG was quantified at the start (prior to treatment) and at completion of the treatment. After chemotherapy, urinary 8- was similar regardless of the treatment regimen: 7-day (25.96±4.21 ng/dL to 28.16±5.27 ng/dL), 14-day (27.76±5.33 ng/dL to 31.56±4.47 ng/dL) and 21-day (27.22±4.16 ng/dL to 31.40±4.24 ng/dL). All in all, higher 8-OHdG levels in the urine connect elevated oxidative stress to both diabetes mellitus and cancer and therapy also seems to further cause this oxidative damageDr.Aadil Ashraf@gmail.comResearch922019Diabetic, Cancer, Urine, TreatmentDr. Kumarasingam and Dr. Aadil AshrafAssistant Professor, Department of Pharmacology, Sree Balaji Medical College & Hospital, Chennai – 600044