333EVALUATION OF THE ANTI-PARKINSONIAN ACTIVITY OF FICUS PUMILA L. VIA MONOAMINE NEUROTRANSMITTER ENZYME INHIBITIONParkinson’s disease (PD) is a progressive neurodegenerative disorder characterised by the loss of dopaminergic neurons in the substantia nigra, leading to motor impairments and oxidative stress-induced neuronal damage. The present study investigates the neuroprotective potential of Ficuspumila ethanol extract (EFP) in a 6-OHDA-induced Parkinsonian rat model. Behavioural assessments, including circling behaviour, rotarod performance, and catalepsy tests, were conducted to evaluate motor function. Biochemical analysis measured MAO-B activity, dopamine concentration, and antioxidant enzyme levels. The results revealed that EFP treatment significantly improved motor coordination, reduced circling behaviour, and prolonged retention time on the rotarod. Additionally, EFP administration reduced lipid peroxidation and enhanced antioxidant enzyme activity (superoxide dismutase, catalase, and glutathione reductase), thereby mitigating oxidative stress. Furthermore, EFP inhibited MAO-B activity, preserving dopamine levels and protecting dopaminergic neurons from degeneration. These findings indicate that Ficuspumila extract exhibits both neuroprotective and regenerative effects, supporting its potential as an adjunct therapeutic agent for Parkinson’s disease management.Manjare@gmail.comResearch922019Ficuspumila, 6-OHDA, Parkinson activities. Parkinson’s disease Ficuspumila. 6-OHDA, MAO-B inhibition, Antioxidant activity.Dr. Manjare Rahul MarutiAssistant Professor, Department of Pharmacology, Sree Balaji Medical College & Hospital, Chennai – 600044, Tamil Nadu, India.