346IN-SILICO PREDICTION, MOLECULAR DOCKING STUDIES ON MIMUSOPS ELENGI LEAVES AGAINST ANTI-ARTHRITIS ACTIVITYArthritis is a chronic inflammatory condition affecting joints, leading to pain, Swelling, and disability. Current therapies rely heavily on synthetic drugs, which are associated with side effects and limited efficacy. In this study, phytoconstituents of mimusopselengi (Spanish cherry), a traditional medicinal plant known for its anti-inflammatory and analgesic properties, were evaluated through computational approaches. Ten bioactive compounds were identified, and their pharmacokinetic (ADME) properties were analysed using Swiss ADME, followed by molecular docking studies against arthritis related protein targets retrieved from the protein data bank. The results revealed that orientin (-8.2675 kcal/mol) and myricetin (-8.0070 kcal/mol) exhibited the highest binding affinity, surpassing other tested compounds. These findings support the potential of mimusops elengi phytoconstituents as lead candidates for anti-arthritic drug development.Dr. Suresh V @gmail.comResearch1522025Anti-arthritis, Mimusopselengi, Phytoconstituents, Molecular docking, Targeted proteins, Swiss dock, Binding affinityDr. Suresh V, Dr. Senthil Kumar S.K,Devi R,Dhanasekar S, Ganesh C,Gokul P,Gokulakrishnan NAssistant Professor, Head of the Department of Pharmacology, Arunai College of Pharmacy, Tiruvannamalai, Tamilnadu, India,Principal, Department of pharmaceutics, ArunaiCollege of Pharmacy, Tiruvannamalai, Tamilnadu, India,B.Pharmacy Final Year Students, Arunai College of Pharmacy, Tiruvannamalai, Tamilnadu, India,B.Pharmacy Final Year Students, Arunai College of Pharmacy, Tiruvannamalai, Tamilnadu, India,B.Pharmacy Final Year Students, Arunai College of Pharmacy, Tiruvannamalai, Tamilnadu, India,B.Pharmacy Final Year Students, Arunai College of Pharmacy, Tiruvannamalai, Tamilnadu, India,B.Pharmacy Final Year Students, Arunai College of Pharmacy, Tiruvannamalai, Tamilnadu, India