348IN-SILICO SCREENING OF PLANT-DERIVED COMPOUNDS AGAINST MYCOBACTERIUM TUBERCULOSIS DPPAThis research discusses the prospect of plant-based compounds; Thymol, Carvacrol, and Isoniazid, to inhibit Mycobacterium tuberculosis DppA by using molecular docking simulations. The findings indicate that Thymol had the most binding affinity with Isoniazid having the best hydrogen bonding interactions. These results indicate that natural compounds, especially those of Plectranthus amboinicus, have the potential as adjunctive TB treatment. Nevertheless, they need additional experimental confirmation that could prove their efficiency and clinical usefulnesspranathishiva3678@gmail.comResearch1422024Molecular docking, Mycobacterium tuberculosis, Thymol, Carvacrol, IsoniazidDr. Vijayalakshmi N,Nagendra Babu Battula,Veena K, Levaku Pranathi,Vadla Phani DeepthiAssistant Professor. (A), JNTUA-Oil Technological & Pharmaceutical Research Institute, Anantapur, Andhra Pradesh, India- 515001,Assistant Professor. (A), JNTUA-Oil Technological & Pharmaceutical Research Institute, Anantapur, Andhra Pradesh, India- 515001,Assistant Professor. (A), JNTUA-Oil Technological & Pharmaceutical Research Institute, Anantapur, Andhra Pradesh, India- 515001,Assistant Professor. (A), JNTUA-Oil Technological & Pharmaceutical Research Institute, Anantapur, Andhra Pradesh, India- 515001,Assistant Professor. (A), JNTUA-Oil Technological & Pharmaceutical Research Institute, Anantapur, Andhra Pradesh, India- 515001