36OSTEOARTHRITIS –A MINIREVIEWOsteoarthritis is more common in women than men but the prevalence increases dramatically with age. 45% of women over the age of 65 have symptoms while radiological evidence is found in 70% of those over 65 years. Osteoarthritis of the knee is a major cause of mobility impairment, particularly among females. The present study is a mini-review to describe the current drug therapy, pathogenesis, clinical manifestation and risk factors of osteoarthritis. We conducted a search of the Delnet library for article published between 2000 and 2013. Using the key phrases; epidemiology, clinical manifestations, diagnosis, pharmacological and non-pharmacological therapy. All relevant publications were retrieved and their bibliography was scanned for additional sources. The process of selecting articles involved three stages; i) Title review ii) Abstract review and iii) Article review, with specific rejection criteria for each of these stages. Generally studies were excluded if they i) were not written in English ii) were presented only in abstract form iii) literature review not focused on human or human cells. Our article suggests that, more research should be carried out in therapeutic management of osteoarthritis.fathimaishrath786@gmail.comReview412014Osteoarthritis,Epidemiology,Clinical Manifestations,DiagnosisFathima Ishrath,Vijaya Kumar SDepartmentof Pharmacy Practice, MGM Hospital, VCOP, Warangal, Andhra Pradesh, India.,Departmentof Pharmacy Practice, MGM Hospital, VCOP, Warangal, Andhra Pradesh, India.