44THE ANTIOXIDANT REVOLUTION - TO PROTECT AGAINST DISEASES & TO MAINTAIN OPTIMUM HEALTH AND WELLBEINGAntioxidants are our first line of defense against free radical damage, and are critical for maintaining optimum health and wellbeing. The need for antioxidants becomes even more critical with increased exposure to free radicals. Pollution, cigarette smoke, drugs, illness, stress, and even exercise can increase free radical exposure. Because so many factors can contribute to oxidative stress, individual assessment of susceptibility becomes important. Antioxidants terminate the chain reactions by removing free radical intermediates, and inhibit other oxidation reactions. They do this by being oxidized themselves, so antioxidants are often called as reducing agents such as thiols, ascorbic acid or polyphenols. Antioxidants are widely used as ingredients in dietary supplements and have been investigated for the prevention of diseases such as cancer, coronary heart disease and even altitude sickness. Many experts believe that the Recommended Dietary Allowance (RDA) for specific antioxidants may be inadequate and, in some instances, the need may be several times the RDA. As part of a healthy lifestyle and a well-balanced, wholesome diet, antioxidant supplementation is now being recognized as an important means of improving free radical protection. Damage to cells caused by free radicals is believed to play a central role in the aging process and in disease progression. The present paper Reviews the Role of Antioxidants in maintaining optimum health and wellbeing.govindbbd@gmail.comReview412014Free Radicals,Oxidative Stress,AntioxidantsGovind shukla,Sangita Kumari,Anna Victoria Zamora Maguddayao,Shivani Prashar,C.J Sampath Kumar,Sunil YadavResearch Scholar, JNTU, Hyderabad, Andhra Pradesh, India,Research Scholar, JNTU, Hyderabad, Andhra Pradesh, India,Head (RA&QA), Pharmasan Inc 525 A de Guzman St, Parang Marikina City Philippines.,Sr. Product Executive, Shrey Neutraceuticals Pvt. Ltd. New Delhi, India., Managing Director, Lactonova India Hyderabad, Andhra Pradesh, India.,Medical officer-in-charge, BPHC Bamore Jhansi, U.P, India.