46IN VIVO SCREENING OF HYPOGLYCAEMIC ACTIVITY OF COCHLOSPERUM VITIFOLIUM ON ALLOXAN-INDUCED DIABETIC RATSIn this present study, saponin extract from the leaf of Cochlosperum vitifolium was evaluated for antidiabetic activity in Wistar albino rats. Diabetes was induced in rats by single intraperitoneal injection of alloxan (150mg/kg body weight). Three days after alloxan induction, the hyperglycemic rats were treated with metformin, a standard antidiabetic drug and extract orally at the dose of 200, 400 and 600 mg/kg body weight daily for 7 days. The fasting blood glucose levels were measured on the 3rdand 7thday during the 7 days treatment. Serum biochemical parameters such as alanine Transaminase (ALT), Aspartate Transaminase (AST), Alkaline Phosphatase (ALP), and total protein were estimated. The present study infers that extract from the leaf of Cochlosperum vitifolium demonstrated remarkable antidiabetic activity even more than a standard antidiabetic drug in alloxan-induced diabetic rats. Consequently, this plant may be of value in diabetes treatment.naik.as@gmail.comResearch412014Antidiabetic,Cochlosperum vitifolium,AlloxanV. Padmaja,M.C.Eshwar,AS.NaikVaagdevi Institute of Pharmaceutical Sciences, Warangal, Andhra Pradesh, India.,Anurag College of Pharmacy, Kodad, Andhra Pradesh, India.,Sathavahana University. Karimnagar, Andhra Pradesh, India.