52ASSESSMENT OF ANTIDEPRESSANT ACTIVITY OF METHANOL AND AQUEOUS EXTRACT OF TECOMA STANS FLOWERS USING TAIL SUSPENSION TEST AND FORCED SWIM TESTAim: Flowers of Tecoma stans Linn popularly known as "yellow bell flowers" contain flavonoids. Flavonoids have been established to have antidepressant activity. The aim of the current study is to evaluate the antidepressant activity of Tecoma stans flowers with possible involvement of monoamines. Materials and Methods: Anti-depressant activity of methanol extract of Tecoma stans (METS) (30 and 100 mg/kg) and aqueous extract of Tecoma stans (AETS) (30 and 100 mg/ kg) were evaluated in mice using behavioral tests such as tail suspension test (TST) and forced swim test (FST). The mechanism of action involved in antidepressant activity was investigated by observing the effect of extract after pretreatment with low dose haloperidol, prazosin and para-chlorophenylalanine (p-CPA). Results: Present study exhibited momentous lessen in immobility time in TST and FST, similar to that of imipramine (10 mg/kg, i.p.) which served as a positive control. The extract significantly attenuated the duration of immobility induced by Haloperidol (50 μg/ kg, i.p., a classical D 2 -like dopamine receptor antagonist), Prazosin (62.5 μg/kg, i.p., an α1 -adrenoceptor antagonist) and pchlorophenylalanine (100 mg/kg, i.p., × 3 days; an inhibitor of serotonin synthesis) in both TST and FST. Conclusion: It can be accomplished that METS and AETS possess potential antidepressant activity (through dopaminergic, noradrenergic and serotonergic mechanisms) and has therapeutic probable in the treatment of CNS disorders and provides evidence at least at preclinical levels.kamesh.pharm@gmail.comResearch422014Aqueous,Dopamine,Flavonoids,Serotonin,Tecoma stansS.Kameshwaran,R.Sundaraganapathy,S.Thenmozhi,M.Dhanalakshmi,K.Vasuki,C.Dhanapal Department of Pharmacology, wamy Vivekanandha College of Pharmacy, Elayampalayam, Thiruchengode, Namakkal, Tamilnadu, India.,Departmentof Pharmaceutical Chemistry, wamy Vivekanandha College of Pharmacy, Elayampalayam, Thiruchengode, Namakkal, Tamilnadu, India.,Departmentof Pharmacognosy,wamy Vivekanandha College of Pharmacy, Elayampalayam, Thiruchengode, Namakkal, Tamilnadu, India.,Department of Pharmaceutics, Swamy Vivekanandha College of Pharmacy, Elayampalayam, Thiruchengode, Namakkal, Tamilnadu, India,Departmentof Pharmacognosy,wamy Vivekanandha College of Pharmacy, Elayampalayam, Thiruchengode, Namakkal, Tamilnadu, India.,Department of Pharmacology, JKKMMRFCP, Kumarapalaym, Namakkal, Tamilnadu, India.