56INFLUENCE OF DIFFERENT FORMULATION VARIABLES ON SUSTAINED RELEASE CIPROFLOXACIN HYDROCHLORIDE MICROSPHERESMicrospheres were prepared by solvent evaporation method. Ciprofloxacin hydrochloride is a first generation Fluroquinolone having a plasma half-life of three to five Thus, development of controlled release dosage forms would clearly be advantageous. The aim of this study was to formulate and evaluate Ciprofloxacin HCL microspheres using Meth acrylic acid esters (Eudragit L 100) as the retardant materials. The prepared microspheres were evaluated for drug content and entrapment efficiency. The in vitro release study was performed in pH 7.4, phosphate buffer. Scanning electron microscopy study revealed that the microspheres were spherical and porous in nature. The results show that, Effect of different types, and ration of Stabilizers, stirring time, Stirring Speed found to have significant effects on entrapment efficiency, particle size and practical yield of microspheres. The yield percent, the actual drug content and the incorporation efficiencies of the prepared microspheres increased with increasing the drug: polymer ratio.kamleshwadher@gmail.comResearch422014Ciprofloxacin HCL,Eudragit L 100,Solvent Evaporation Technique, Stirring timeKamlesh J Wadher,Atul Nagarkar,Durgesh Sahare, Milind J UmekarDepartment of Pharmaceutical Technology, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, 441002, India.,Department of Pharmaceutical Technology, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, 441002, India.,Department of Pharmaceutical Technology, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, 441002, India.,Department of Pharmaceutical Technology, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, 441002, India.