67CHANGING TRENDS OF DRUGS CAUSING FIXED DRUG REACTIONS REPORTED AT A TERTIARY CENTRE, GUJARAT, INDIADrug reactions are very frequently seen by physicians in day to day practice. Fixed drug eruption is a distinctive type of adverse cutaneous reaction to an ingested drug that occurs in the same locations upon reexposure to the offending drug, though usually not fatal, can cause enough cosmetic embarrassment if present on the exposed part due to residual hyperpigmentation. To find out the most common drugs responsible for the fixed drug reactions along with the most common sites. The study was carried out from April 2010 to March 2011 in the Department of Dermatology, Venereology and Leprology of Shri Krishna Hospital attached to Pramukhswami Medical College, Karamsad, Gujarat, India. 23 patients of FDR were studied. Diclofenac was the most common drug causing fixed drug reaction. Other drugs found to cause reaction includes Cotrimoxazole, Norfloxacin, Metronidazole, Doxycycline, Ornidazole, Paracetamol, Ibuprofen, Chloroquine and Fluconazole. The commonest lesions were hyperpigmented patches over genitals. This study helps to investigate the drug causing FDR with particular clinical pattern more accurately, especially those with a multi-drug history.ritavv@charutarhealth.orgResearch432014Adverse Cutaneous drug reactions,Hyperpigmentation, Offending DrugAbhishek Pilani,Gopikrishnan A,Rita VoraDepartment of Dermatology, PS Medical College and Shree Krishna Hospital, Karamsad, Anand. Gujarat-388325, India.,Department of Dermatology, PS Medical College and Shree Krishna Hospital, Karamsad, Anand. Gujarat-388325, India.,Department of Dermatology, PS Medical College and Shree Krishna Hospital, Karamsad, Anand. Gujarat-388325, India.