69ANTIOXIDATIVE BURST, CYTOTOXIC AND ANTILEISHMANIAL ACTIVITIES OF ELEUSCINE INDICAThe ethanol leaf extract of Eleuscine indica were investigated for cytotoxicity activity against HeLa cells using SRB method. Antioxidative burst activity of the extract in whole blood, neutrophils and macrophages was also investigated using luminol/lucigenin-based chemiluminescence assay. The ethanol extract was similarly screened for antileishmanial activity against promastigotes of Leishmania major In Vitro. The ethanol leaf extract was found to exert moderate cytostatic activity. The ethanol crude extract significantly inhibited oxidative burst activity in whole blood (p<0.05 – 0.001), isolated polymorphonuclear cells (PMNs) (p<0.01 – 0.001) and mononuclear cells (MNCs) (p<0.05 – 0.001) when two different phagocytosis activators (serum opsonizing zymosan-A and PMA) were used. The ethanol crude extract also exhibited moderate antileishmanial activity against promastigotes of Leishmania major In Vitro. These results suggest that the leaf extract of Eleuscine indica possess antioxidative burst and moderate cytostatic and antileishmanial activitiesjudeefiom@yahoo.comResearch432014Eleuscine indica,Cytotoxicity,Antioxidant,AntileishmanialJude E. Okokon,Anwanga E. Udoh,Ette O. Etebong, Azare B.ADepartment of Pharmacology and Toxicology Faculty of Pharmacy, University of Uyo, Uyo, Nigeria.,Department of Pharmacology and Toxicology Faculty of Pharmacy, University of Uyo, Uyo, Nigeria.,Department of Pharmacology and Toxicology Faculty of Pharmacy, University of Uyo, Uyo, Nigeria.,Department of Biological Sciences, University of Abuja, Nigeria.