89EVALUATION OF HEPATOPROTECTIVE AND ANTIOXIDANT ACTIVITY OF THE BARK OF DELONIX ELATA (L) GAMBLEThe effect of ethanolic extract of bark of Delonix elata (EEBDE) was screened using CCl4 induced acute and chronic hepatotoxicity in rats, lipid peroxidation and reduced glutathione assay. The acute oral toxicity study was carried out in order to know the LD50 value of the EEBDE. The phytoconstituents studies were conducted and it revealed the presences of phenolic, steroids, flavonoids, alkaloids and glycosides. Oral doses of the EEBDE (200mg/kg and 400 mg/kg b.w) has given to the wistar albino rats and then challenged with CCl4 (2ml/kg i.p). The estimation of SGPT, SGOT, ALP, TSP and serum bilirubin levels were carried out to measure the extent of hepatoprotection against CCl4 induced toxicity. Further histopathological studies were also carried out validate the study. The antioxidant activity was assessed by measuring the tissue LPO and GSH levels in rats. A significant reduction in the levels of SGPT, SGOT, ALP Total and Direct bilirubin were found in treated groups of 200mg and 400mg of EEBDE compared to CCl4 induced rats. There was an increase in the TSP levels observed with EEBDE treatment (200 and 400 mg/kg b.w) compared to CCl4 induced rats. A significant increase in the GSH level and a decrease in the LPO levels were also observed with the both doses of EEBDE treated groups. The protective action brought by the EEBDE may be due to the prelakshminarayana089@gmail.comResearch522015Delonix elata,Acute and Chronic toxicity,Hepatoprotective activity,SilymarinBharathi BR,Chandrashekhar M Sultanpur,Lakshminarayana GPharmacology department, Government College of Pharmacy, Bangalore-560027, Rajiv Gandhi University of Health Sciences, Karnataka, India.,Pharmacology department, Government College of Pharmacy, Bangalore-560027, Rajiv Gandhi University of Health Sciences, Karnataka, India.,Pharmacology department, Government College of Pharmacy, Bangalore-560027, Rajiv Gandhi University of Health Sciences, Karnataka, India.