8ANTI-SECRETORY PROPERTIES OF MACARANGA PELTATA ROXB. IN VARIOUS EXPERIMENTAL MODELSMacaranga peltata Roxb. a member of the Euphorbiaceae family, is used in folk medicine because of its treatment in ulcer. The purpose of the present study is to investigate the acute oral toxicity and anti-ulcer profile of the Petroleum Ether Extract of Macaranga peltata Roxb. (PMP ) extract in albino rats. Study on acute toxicity of extract found to be safe at the doses 2000mg/kg body weight orally as per OECD guidelines No.423. PMP at the doses of 200 and 400 mg/kg body weight orally was administered to evaluate anti-ulcer activity by using Ethanol, indomethacin, pyloric ligation (PL), and coldrestraint stress induced gastric ulcer models in Albino rats. Petroleum Ether Extract of Macaranga peltata Roxb. dose dependent inhibition in Ethanol, indomethacin, pyloric ligation (PL), and cold-restraint stress induced gastric lesions in rats. All the results are found to be statistically significant (p≤0.05). Hence we suggest that Petroleum Ether Extract of the leaves of Macaranga peltata Roxb.possess anti-ulcer properties that may be due to cytoprotective mechanism. These results support the ethnomedical uses of the plant in the treatment of gastric ulcer.swamilingam@gmail.comResearch212012Macaranga peltata Roxb,Ethanol,Indomethacin,Pyloric ligation,Cold-restraint stress induced gastric lesionsJ. Saminathan,T. VetrichelvanAdhiparasakthi College of Pharmacy, Melmaruvathur, Tamil Nadu - 603 319, India.,Adhiparasakthi College of Pharmacy, Melmaruvathur, Tamil Nadu - 603 319, India.