93ANTIMICROBIAL RESISTANCE AMONGST HUMAN PATHOGENS: A MATTER OF SERIOUS CONCERNThe resistance against antibiotics amongst pathogenic microorganism is increasing at an alarming rate. A strong correlation between the use of antibiotics in the treatment of diseases and development of antibiotic resistance has been observed. The resistance to antibiotics can be natural, acquired, genetic, phenotypis or biological. The resistance may develop due to spontaneous mutation in gene, acquisition of plasmid or transposon, change in the physiological state of bacterial cell or reduced permeability of cell. The various drug inactivation mechanisms involve enzymatic hydrolysis of antibiotics, group transfer, ribosome protection and biofilm formation. There are several non-antibiotic approaches with specific regard to antimicrobials to the treatment and prevention of infection including probiotics, bacteriophages, and phytomedicines.seemamillenium@gmail.comResearch522015Antibiotics,Pathogenic microorganisms,Biofilm formation,Phytomedicine,ProbioticsSeema Rawat,Sapna SwarupDepartment of Botany and Microbiology, H.N.B Garhwal (Central) University, Srinagar, Uttarakhand, India,Department of Microbiology, Dolphin (PG) Institute of Biomedical & Natural Sciences, Dehradun, India.