9PROTECTIVE EFFECT OF VIGNA MUNGO (L.) AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITYVigna Mungo Linn. (Leguminosae) is widely distributed in tropical West Africa and extensively cultivated all over India. It is commonly known as Black gram, Urad and Udid. To investigate the hepatoprotective activity and acute oral toxicity of extract of leaves of Vigna Mungo (PVM) in male Wistar albino rats by using CCl4 induced hepatoptoxicity. The PVM at doses of 200 and 400mg/kg, p.o and the standard drug Silymarin (100mg/kg, p.o) were administered three times at 12h intervals and then CCl4 (1ml/kg) was administered to all the groups except normal control for 2 days. The hepatoprotective activity was assessed by using various biochemical parameters like SGOT, SGPT, ALP, γ-GT, TP and total bilirubin along with histopathological studies were observed after 36h of CCl4 treatment. The PVM at the doses of 200 and 400mg/kg inhibited CCl4 induced liver toxicity in Wistar albino rats as assessed by the biochemical changes and histopathological studies. The pet ether extract of leaves of Vigna Mungo afforded significant protection against CCl4 induced hepatocellular injuryanithakakkerla.k@gmail.comResearch212012Vigna Mungo,Hepatoprotective,CCl4,Silymarin,HepatotoxicityAnitha.K,Ranjith.K,Vakula.K,Thirupathi.G,B.BalajiDept. of Pharmaceuticals – Jayamukhi Institute of Pharmaceutical Sciences, Warangal, Andhra Pradesh, India,Dept. of Pharmaceuticals – Jayamukhi Institute of Pharmaceutical Sciences, Warangal, Andhra Pradesh, India,Dept. of Pharmaceuticals – Jayamukhi Institute of Pharmaceutical Sciences, Warangal, Andhra Pradesh, India,Dept. of Pharmacology - Vaagdevi Institute of Pharmaceutical Sciences, Warangal, Andhra Pradesh, India.,Dept. of Pharmaceutical Chemistry - Vaagdevi Institute of Pharmaceutical Sciences, Warangal, Andhra Pradesh, India.